Detail
| LncRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618 |
| Region | GRCh38_22:30969245-30979395 Sequence |
| Ensembl | ENSG00000253352 |
| RefSeq | NR_002323 |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder urothelial cancer |
| ICD-0-3 | M8120/3 |
| Methods | qPCR, Western blot, Luciferase assay etc. |
| Sample | Human BUC T24 cell lines, BUC tissues |
| Expression Pattern | up-Regulated |
| Function Description | In conclusion, up-regulation of lncRNA TUG1 was related with the poor response of BUC patients to Dox chemotherapy, knockdown of TUG1 inhibited the Dox resistance of BUC cells via Wnt/B-catenin pathway. These findings might assist in the discovery of novel potential diagnostic and therapeutic target for BUC, thereby improve the effects of clinical treatment in patients. |
| Pubmed ID | 29179467 |
| Year | 2017 |
| Title | Knockdown of long non-coding RNA Taurine Up-Regulated 1 inhibited doxorubicin resistance of bladder urothelial carcinoma via Wnt/B-catenin pathway. |
| External Links |
| Links for TUG1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder urothelial cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.