Detail
| LncRNA Name | BDNF-AS |
| Synonyms | BDNF-AS, ANTI-BDNF, BDNF, BDNF-AS1, BDNFAS, BDNFOS, NCRNA00049, BT2A, BT2B, BT2C, BT2D |
| Region | GRCh38_11:27506838-27698174 Sequence |
| Ensembl | ENSG00000245573 |
| RefSeq | NR_002832 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | prostate cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | BDNF-AS was downregulated in human CaP tumors. Low BDNF-AS expression was correlated with CaP patients' poor prognosis and shorter overall survival. BDNF-AS was also found to be lowly expressed in CaP cell lines. In LNCaP and PC-3 cells, lentivirus-driven BDNF-AS overexpression exerted significantly tumor-suppressing effects on hindering cancer cell proliferation and invasion in vitro, and explant growth in vivo. |
| Pubmed ID | 29710528 |
| Year | 2018 |
| Title | Long noncoding RNA BDNF-AS is associated with clinical outcomes and has functional role in human prostate cancer. |
| External Links |
| Links for BDNF-AS | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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