Detail
| LncRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618 |
| Region | GRCh38_22:30969245-30979395 Sequence |
| Ensembl | ENSG00000253352 |
| RefSeq | NR_002323 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 M8070/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Both tumors, OSCC cell lines (HN4, HN6, SCC-25, CAL-27, NHOK) |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, our data revealed that TUG1 confers oncogenic function in OSCC and TUG1/miR-219/FMNL2 axis may be a novel therapeutic strategy in this disease.Clinically, the expression of TUG1 and FMNL2 were increased, but miR-219 was decreased in primary tumors compared to non-tumor tissues. Both the upregulated TUG1, and FMNL2 and the downregulated miR-219 was associated with advanced stage of OSCC and poor overall survival.Increasing evidences indicated that the dysregulated lncRNAs and miRNAs were correlated with tumor progression and cancer-related cellular process, including proliferation, apoptosis, migration, and invasion. |
| Pubmed ID | 28979812 |
| Year | 2017 |
| Title | Long non-coding RNA TUG1 promotes progression of oral squamous cell carcinoma through upregulating FMNL2 by sponging miR-219 |
| External Links |
| Links for TUG1 | GenBank HGNC lncrnadb Noncode |
| Links for oral squamous cell carcinoma | Omim Cosmic |
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