Detail
| LncRNA Name | BDNF-AS |
| Synonyms | BDNF-AS, ANTI-BDNF, BDNF, BDNF-AS1, BDNFAS, BDNFOS, NCRNA00049, BT2A, BT2B, BT2C, BT2D |
| Region | GRCh38_11:27506838-27698174 Sequence |
| Ensembl | ENSG00000245573 |
| RefSeq | NR_002832 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oesophageal cancer |
| ICD-0-3 | M8070/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot, etc. |
| Sample | Normal oesophageal epithelial cell line (SHEE), eight EC cell lines (OE19, KYSE-70, KYSE-170, KYSE-180, OE33, Eca-109, TE-1, TE-13). EC tissues. |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of BDNF-AS was found to suppress cell proliferation, invasion and metastasis in vitro and suppress the EMT in EC cells. Further analysis demonstrated BDNF-AS functioned as a miR-214 sponge to positively regulate cell proliferation, metastasis and the EMT. 2 Advances in chemoradiotherapy and surgery could prolong the survival time of patients with EC. |
| Pubmed ID | 29896888 |
| Year | 2018 |
| Title | LncRNA BDNF-AS inhibits proliferation, migration, invasion and EMT in oesophageal cancer cells by targeting miR-214. |
| External Links |
| Links for BDNF-AS | GenBank HGNC lncrnadb Noncode |
| Links for oesophageal cancer | Omim Cosmic |
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