Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name TUG1
   Synonyms TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618
   Region GRCh38_22:30969245-30979395    Sequence
   Ensembl ENSG00000253352
   RefSeq NR_002323
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc.
   Sample CRC tissues, cell lines (HCT116, LoVo, RKO, SW620, and SW480)
   Expression Pattern up-regulated
   Function Description

Here, we reported that TUG1 was upregulated in CRC. Further experiments revealed that TUG1 knockdown significantly inhibited cell proliferation, migration and invasion of CRC in vitro.

   Pubmed ID 27421138
   Year 2016
   Title Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway.
   External Links
   Links for  TUG1 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

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