Detail
| LncRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618 |
| Region | GRCh38_22:30969245-30979395 Sequence |
| Ensembl | ENSG00000253352 |
| RefSeq | NR_002323 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Lentiviral infection, Western blot, RIP, ChIP etc. |
| Sample | glioma tissues, cell lines (hCMEC/D3, astrocytes, brain vascular pericytes) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA TUG1 (taurine upregulated gene 1) was highly expressed in glioma vascular endothelial cells from glioma tissues. It also upregulated in glioma co-cultured endothelial cells (GEC) from BTB model in vitro. Knockdown of TUG1 increased BTB permeability, and meanwhile down-regulated the expression of the tight junction proteins ZO-1, occludin, and claudin-5. TUG1 increased BTB permeability via binding to miR-144 and then reducing EC tight junction protein expression by targeting HSF2. |
| Pubmed ID | 26078353 |
| Year | 2015 |
| Title | The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144. |
| External Links |
| Links for TUG1 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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