Detail
| LncRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618 |
| Region | GRCh38_22:30969245-30979395 Sequence |
| Ensembl | ENSG00000253352 |
| RefSeq | NR_002323 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR, Luciferase reporter assay, in vitro knockdown |
| Sample | BC tissues, BC cell lines (T24, 5637, UMUC-2 and EJ) |
| Expression Pattern | up-regulated |
| Function Description | TUG1 was upregulated and microRNA-29c(miR-29c) was downregulated in BC tissues and cell lines.Furthermore, TUG1 knockdown markedly increased the expression of miR-29c in vitro.On the contrary, overexpression of TUG1 remarkably decreased the expression of miR-29c.Transfection with plasmids containing mutant TUG1 has no effect on the expression of miR-29c. There were direct interactions between miR-29c and the binding sites of TUG1.In addition,the inhibitory effects of small interfering RNA specific for TUG1 on BC cell proliferation,migration and invasion were reversed by downregulation of miR-29c. |
| Pubmed ID | 29321088 |
| Year | 2018 |
| Title | Upregulation of long non-coding RNA TUG1 promotes bladder cancer cell 5 proliferation, migration and invasion by inhibiting miR-29c. |
| External Links |
| Links for TUG1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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