Detail
| LncRNA Name | TUG1 |
| Synonyms | TUG1, LINC00080, NCRNA00080, TI-227H, FLJ20618 |
| Region | GRCh38_22:30969245-30979395 Sequence |
| Ensembl | ENSG00000253352 |
| RefSeq | NR_002323 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, MTT assay etc. |
| Sample | bladder cancer tissues, cell line (T24) |
| Expression Pattern | up-regulated |
| Function Description | We observed significantly increased levels of TUG1 in tumor tissue in comparison to adjacent non-tumor bladder tissue. TUG1 levels were significantly increased in metastatic tumors and were associated with shorter overall survival of MIBC patients. TUG1 silencing in vitro led to 34 % decrease in cancer cell proliferation and 23 % reduction in migration capacity of cancer cells. |
| Pubmed ID | 27460088 |
| Year | 2016 |
| Title | Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer. |
| External Links |
| Links for TUG1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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