Detail
| LncRNA Name | TUNAR |
| Synonyms | TUNAR, HI-LNC78, LINC00617, TUNA |
| Region | GRCh38_14:95876392-95925571 Sequence |
| Ensembl | ENSG00000250366 |
| RefSeq | NR_038861 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Western blot, luciferase reporter assay etc. |
| Sample | cell lines (SHG44, U251, GL15, U87) |
| Expression Pattern | down-regulated |
| Function Description | TUNAR was confirmed to positively regulate miR-200a,and knockdown of miR-200a reversed TUNAR-induced inhibitory effects on glioma cells. Further, Rac1 was negatively regulated by miR-200a.Rac1 overexpression abolished miR-200a overexpression-induced inhibition of viability,migration, and invasion, as well as increase of apoptosis.Besides,Rac1 knockdown inhibited glioma by inactivating the Wnt/B-catenin and NF-kB signal pathways.TUNAR played an anti-cancer role in glioma cells by upregulating miR-200a and inhibiting Rac1,thereby might represent a potential therapeutic target for the treatment of human glioma. |
| Pubmed ID | 29540255 |
| Year | 2018 |
| Title | Long non-coding RNA TUNAR represses growth, migration and invasion of human glioma cells through regulating miR-200a and Rac1. |
| External Links |
| Links for TUNAR | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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