Detail
| LncRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295, LOC285194 |
| Region | GRCh38_3:116709235-116723581 Sequence |
| Ensembl | ENSG00000243197 |
| RefSeq | NR_015391 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma multiforme |
| ICD-0-3 | M9440/3 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell line (U87), GBM tissues |
| Expression Pattern | down-regulated |
| Function Description | Low expression of TUSC7 in GBM cells and tissues resistant to TMZ.Upregulation of TUSC7 suppressed both TMZ resistance and expression of multidrug resistance protein 1 (MDR1) in U87TR cells.TUSC7 acted by directly targeting and silencing expression of miR-10a gene,and miR-10a mediated TUSC7-induced inhibition on TMZ resistance in U87TR cells. |
| Pubmed ID | 29397407 |
| Year | 2018 |
| Title | Long non-coding RNA TUSC7 inhibits temozolomide resistance by targeting miR-10a in glioblastoma. |
| External Links |
| Links for TUSC7 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma multiforme | Omim Cosmic |
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