Detail
| LncRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295, LOC285194 |
| Region | GRCh38_3:116709235-116723581 Sequence |
| Ensembl | ENSG00000243197 |
| RefSeq | NR_015391 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, RIP, luciferase reporter assays |
| Sample | ESCC cell lines (TE-13, KYSE140, EC9706, KYSE30, Het-1A), ESCC tissues |
| Expression Pattern | down-regulated |
| Function Description | TUSC7 was downregulated in ESCC tissues and cells,and low TUSC7 indicated worse overall survival.TUSC7 specifically bound to miR-224, and we proved miR-224 was upregulated in ESCC and negatively correlated with TUSC7 expression.Overexpression of TUSC7/inhibition of miR-224 suppressed cell proliferation,colony formation and chemotherapy resistance of ESCC cells,and promoted cell apoptosis.TUSC7 suppressed the proliferation and chemotherapy resistance of ESCC cells by increasing DESC1 expression via inhibiting miR-224.TUSC7 suppressed chemotherapy resistance of ESCC by downregulating miR-224 to modulate DESC1/EGFR/AKT pathway. |
| Pubmed ID | 29530057 |
| Year | 2018 |
| Title | LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1. |
| External Links |
| Links for TUSC7 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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