Detail
| LncRNA Name | TUSC7 |
| Synonyms | TUSC7, LINC00902, LSAMP-AS1, LSAMP-AS3, LSAMPAS3, NCRNA00295, LOC285194 |
| Region | GRCh38_3:116709235-116723581 Sequence |
| Ensembl | ENSG00000243197 |
| RefSeq | NR_015391 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR etc. |
| Sample | colorectal cancer cell lines (HT29, SW480, SW620, DLD-1) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we indicated that the expression of TUSC7 was downregulated in colorectal cancer cell lines and tissues. Moreover, the expression of TUSC7 was lower in the high-grade (Dukes C and D) colorectal cancer patients compared to that in the low-grade colorectal cancer patients (Dukes A and B). Colorectal cancer patients with a lower level of TUSC7 expression had worse overall survival rate. In addition, we demonstrated that overexpression of TUSC7 inhibited the expression of miR-10a and enhanced the expression of PTEN and EphA8, which were the direct target genes of miR-10a.The colorectal cancer patients with lower TUSC7 expression had worse overall survival rate compared with those with high TUSC7 expression.Increasing studies suggested that lncRNA played as a ceRNA to modulate miRNAs in tumor development |
| Pubmed ID | 28979678 |
| Year | 2017 |
| Title | TUSC7 acts as a tumor suppressor in colorectal cancer. |
| External Links |
| Links for TUSC7 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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