Detail
LncRNA Name | uc.57 |
Synonyms | ADARB2-AS1, bA466B20.1 |
Region | GRCh38_10:1526637-1556984 Sequence |
Ensembl | ENSG00000205696 |
RefSeq | NR_033387 |
Circulating | ✘ |
Drug-resisitant | ✔ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot, RIP etc. |
Sample | breast cancer tissues, cell line (MCF-7, MCF-7R) |
Expression Pattern | down-regulated |
Function Description | uc.57 binds to BCL11A. Uc.57 overexpression downregulated BCL11A and reduced tamoxifen resistance in MCF-7R cells both in vitro and in vivo. |
Pubmed ID | 29179465 |
Year | 2017 |
Title | Shikonin reduces tamoxifen resistance through long non-coding RNA uc.57 |
External Links |
Links for uc.57 | GenBank HGNC lncrnadb Noncode |
Links for breast cancer | Omim Cosmic |
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