Detail
| LncRNA Name | UC001kfo |
| Synonyms | ACTA2-AS1, ZXF1, uc001kfo.1 |
| Region | GRCh38_10:88932390-88940820 Sequence |
| Ensembl | ENSG00000180139 |
| RefSeq | NR_125373 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, MTT assay etc. |
| Sample | HCC tissues, cell lines (GSG701, Hep3B, HepG2, Huh7, SMMC 7721 and HCC LM3) |
| Expression Pattern | up-regulated |
| Function Description | The expression of UC001kfo was upregulated in HCC tissues and cell lines in comparison with tumour-adjacent tissues and normal hepatocytes, respectively. In addition, a high UC001kfo level was determined to be correlated with macro-vascular invasion and TNM stage of HCC. In addition, UC001kfo was verified to promote the proliferation, metastasis and epithelial-mesenchymal transition (EMT) in HCC cells in both in vitro and in vivo assays. Mechanistically, a-SMA was indicated as a potential target gene of UC001kfo in mediating HCC metastasis. |
| Pubmed ID | 28088733 |
| Year | 2017 |
| Title | Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting a-SMA. |
| External Links |
| Links for UC001kfo | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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