Detail
| LncRNA Name | uc002yug.2 |
| Synonyms | LINC01426, lincRNA-uc002yug.2 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | We found that lincRNA-uc002yug.2 was commonly overexpressed in ESCC. Moreover, lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPa (CCAAT/enhancer-binding protein-a) gene expression, thereby promoting ESCC progression. The expression levels of lincRNA-uc002yug.2 in ESCC might be a prognostic factor for survival. |
| Pubmed ID | 25486427 |
| Year | 2014 |
| Title | LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis. |
| External Links |
| Links for uc002yug.2 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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