Detail
| LncRNA Name | BLACAT1 |
| Synonyms | BLACAT1, LINC00912, UBC1, onco-lncRNA-30, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 Sequence |
| Ensembl | ENSG00000281406 |
| RefSeq | NR_103783 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C54 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cervical cancer tissues, cell line (HeLa, CaSki, SiHa, ME-180 and H8) |
| Expression Pattern | up-regulated |
| Function Description | We found that BLACAT1 expression was significantly increased in CC tissues and cells lines. In addition, the expression level of BLACAT1 was positively correlated with distant metastasis (p=0.001), FIGO stage (p=0.010), and histological grade (p=0.012). Moreover, patients with high BLACAT12 expression had shorter overall survival and progression-free survival time than those with low BLACAT1 expression, with the data provided by multivariate analysis suggesting that BLACAT1 expression could serve as an independent prognostic factor in CC patients. Functionally, in vitro assay indicated that down-regulation of BLACAT1 significantly suppressed CC cells proliferation, migration, and invasion. Mechanistically, the results of Western blot showed that the expression of B-catenin and MMP-7 was significantly down-regulated in CC cells transfected with si-BLACAT1. |
| Pubmed ID | 29863244 |
| Year | 2018 |
| Title | Long non-coding RNA BLACAT1 promotes cell proliferation, migration and invasion in cervical cancer through activation of Wnt/β-catenin signaling pathway. |
| External Links |
| Links for BLACAT1 | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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