UCA1 was significantly overexpressed in gallbladder cancer (GBC) and positively correlated with tumor size, lymph node metastasis,TNM stage and short survival time. UCA1 promoted GBC progression through recruiting enhancer of zeste homolog 2 (EZH2) to the promoter of p21 and E-cadherin, and epigenetically suppressing their transcript.The â??spongeâ?? role of UCA1 in cytoplasm had been investigated more than once. Through binding to microRNAs (miRNAs) response elements that could directly suppress their target protein expression, UCA1 has an oncogenic function on various human cancers, such as bladder cancer, non-small cell lung cancer, hepatocellular carcinoma and etc.