Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | epithelial squamous carcinoma |
| ICD-0-3 | M8070/3 |
| Methods | qPCR, Western blot, Northern blot, Flow cytometry assay etc. |
| Sample | cell lines (A431, A10A) |
| Expression Pattern | up-regulated |
| Function Description | CUDR was found to be overexpressed in a doxorubicin-resistant subline of human squamous carcinoma A431 and A10A cells, which were also more resistant to drug-induced apoptosis. Stable transfection with the CUDR gene was found to induce resistance to doxorubicin and etoposide as well as drug-induced apoptosis in A431 cells. By Western blot analysis, down-regulations of caspase 3 were observed in CUDR transfectants. On the other hand, overexpression of CUDR promoted anchorage-independent growth in A431 cells. |
| Pubmed ID | 17416635 |
| Year | 2007 |
| Title | Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for epithelial squamous carcinoma | Omim Cosmic |
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