Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi |
| Sample | Cell lines (H520, SKMES1) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 down-regulation inhibited cell proliferation and migration in both SKMES-1 and H520 lung cancer cells.Then we demonstrated that repressed UCA1 promoted the miR-193a expression and miR-193a could bind to the predicted binding site of UCA1.We then dissected the role of miR-193a in lung cancer and proved the anti-tumor role of miR-193a.Furthermore,miR-193a displayed its role in lung cancer via modulating the HMGB1 expression.In addition,over-expression of HMGB1 could restore the UCA1 knockdown induced repression of cell proliferation and migration. |
| Pubmed ID | 29355524 |
| Year | 2018 |
| Title | Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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