Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | luciferase reporter assay, qPCR, western blot etc. |
| Sample | cell lines (WI-38, HEL-1) |
| Expression Pattern | up-regulated |
| Function Description | This result indicated that the up-regulated expression of lncRNA UCA1 was involved in the canceration of normal lung cells. These findings will be helpful for understanding the critical roles of lncRNA UCA1 and miRNA-144 in lung cancer cells, and provide new therapeutic strategy for lung cancer therapy.The experimental study from Cheng et al. demonstrated that lncRNA UCA1 promoted non-T790M cells acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) by activating the AKT/mammalian target of rapamycin (mTOR) pathway in EGFR-mutant NSCLC. |
| Pubmed ID | 28762326 |
| Year | 2017 |
| Title | Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144 |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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