Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Luciferase reporter assay, Flow cytometry assay, in vitro knockdown etc. |
| Sample | osteosarcoma tissues, cell lines (HOS, Saos-2, MG-63, U2OS) |
| Expression Pattern | up-regulated |
| Function Description | We found that lncRNA-UCA1 expression was upregulated in osteosarcoma tissues and cell lines. High lncRNA-UCA1 expression was significantly correlated with large tumor size, high tumor grade, positive distant metastasis, and advanced clinical stage. Multivariate regression analysis identified lncRNA-UCA1 overexpression as an independent unfavorable prognostic factor. lncRNA-UCA1 knockdown inhibited osteosarcoma cell proliferation, promoted cell apoptosis, and suppressed cell invasion and migration, whereas lncRNA-UCA1 overexpression showed opposite effects. |
| Pubmed ID | 27335776 |
| Year | 2016 |
| Title | Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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