Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | cell lines (DU145 and LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 was up-regulated in prostate cancer tissues compared to hyperplastic prostatic tissues,and a higher UCA1 level predicted poor prognosis in PCa patients.Then we determined that the miR-184/Bcl-2 axis might be the downstream signaling pathway of UCA1 upon ART treatment. UCA1 binds to miR-184 through its seed sequences and may function as a sponge for miR-184. |
| Pubmed ID | 28209917 |
| Year | 2017 |
| Title | Artesunate suppresses the viability and mobility of prostate cancer cells through UCA1, the sponge of miR-184 |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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