Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 M8070/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | oral squamous cell carcinoma tissues, cell lines (Tca8113, TSCCA, CAL-27, SCC-9, NHOK) |
| Expression Pattern | up-regulated |
| Function Description | UCA1 expression was upregulated in OSCC tissues, cell lines, and CDDP resistant OSCC cells. UCA1 facilitated proliferation, enhanced CDDP chemoresistance, and suppressed apoptosis in OSCC cells.UCA1 could interact with miR-184 to repress its expression. downregulation of miR-184 partly reversed the tumor suppression effect and CDDP chemosensitivity of UCA1 knockdown in CDDP-resistant OSCC cells.UCA1 could perform as a miR-184 sponge to modulate SF1 expression.depletion of UCA1 further boosted CDDP-mediated repression effect on tumor growth. UCA1 accelerated proliferation, increased CDDP chemoresistance and restrained apoptosis partly through modulating SF1 via sponging miR-184 in OSCC cells. |
| Pubmed ID | 29125238 |
| Year | 2017 |
| Title | LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for oral squamous cell carcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.