Detail
| LncRNA Name | BLACAT1 |
| Synonyms | BLACAT1, LINC00912, UBC1, onco-lncRNA-30, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 Sequence |
| Ensembl | ENSG00000281406 |
| RefSeq | NR_103783 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | microarray, qPCR, RNAi, ISH etc. |
| Sample | bladder cancer tissues, cell lines (J82, UMUC-3, HT-1376, T24, 5637 etc.) |
| Expression Pattern | up-regulated |
| Function Description | qPCR confirmed that linc-UBC1 expression is up-regulated in 60 cases (58.8%) in bladder cancer tissues compared with normal adjacent tissues, and its overexpression correlates with lymph node metastasis and poor survival. Further functional analysis demonstrated that knockdown of linc-UBC1 attenuates bladder cancer cell proliferation, motility, invasion, colony formation ability, tumorigenicity and metastatic potential. RIP and ChIP assay confirmed that linc-UBC1 physically associates with PRC2 complex and regulates histone modification status of target genes. |
| Pubmed ID | 23688781 |
| Year | 2013 |
| Title | linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. |
| External Links |
| Links for BLACAT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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