Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, MTT assay etc. |
| Sample | glioma tissues, cell lines (U373MG, T98MG, SWO38, U251 and SHG44) |
| Expression Pattern | up-regulated |
| Function Description | Upregulation of lncRNA-UCA1 in glioma tissues and cell lines could promote glioma cell proliferation and migration through interaction with miR-182, and knockdown of UCA1 inhibited the proliferation and migration of human glioma cell. In addition, miR-182 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) was required in the regulation of UCA1 induced glioma cell proliferation. |
| Pubmed ID | 28137422 |
| Year | 2017 |
| Title | The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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