Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | cell line (MHCC97, MG63, hFOB1.19, OS-732), neuroblastoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of UCA1 reduced cell viability, inhibited migration and invasion, and promoted cell apoptosis.However,the effect of UCA1 knockdown on cell growth and migration was blocked by miR-301a overexpression,whose expression was regulated by UCA1. We also found that miR-301a positively regulated the CXCR4 expression. CXCR4 inhibition reversed the effect of miR-301a overexpression on cell growth and migration.Moreover,miR-301a activated the Wnt/-catenin and NF-B pathways via regulating CXCR4. |
| Pubmed ID | 29523218 |
| Year | 2018 |
| Title | Knockdown of urothelial carcinoma associated 1 suppressed cell growth and migration through regulating miR-301a and CXCR4 in osteosarcoma MHCC97 cells. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for liver cancer | Omim Cosmic |
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