Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SIBCB), cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Interference of lncRNA UCA1 inhibited cell proliferation,migration,invasion,and viability. Results of the luciferase reporter assay revealed a binding site between lncRNA UCA1 and miR-206. Knockdown of lncRNA UCA1 could directly upregulate miR-206 expression. VEGF downregulation was also observed after knockdown of lncRNA UCA1. |
| Pubmed ID | 29523226 |
| Year | 2018 |
| Title | Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206 expression. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for cervical cancer | Omim Cosmic |
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