Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (MDA-MB-231, T47D and MCF7) |
| Expression Pattern | up-regulated |
| Function Description | In breast cancer cells,IMP1 interacts with UCA1 via the ACACCC motifs within UCA1 and destabilizes UCA1 through the recruitment of CCR4-NOT1 deadenylase complex.Meanwhile,binding of IMP1 prevents the association of miR-122-5p with UCA1,thereby shifting the availability of miR-122-5p from UCA1 to the target mRNAs and reducing the UCA1-mediated cell invasion.Accordingly, either IMP1 silencing or UCA1 overexpression resulted in reduced levels of free miR-122-5p within the cytoplasm, affecting miR-122-5p in regulating its target mRNAs.Our study provides initial evidence that interaction between IMP1 and UCA1 enhances UCA1 decay and competes for miR-122-5p binding,leading to the liberation of miR-122-5p activity and the reduction of cell invasiveness. |
| Pubmed ID | 29669595 |
| Year | 2018 |
| Title | IMP1 regulates UCA1-mediated cell invasion through facilitating UCA1 decay and decreasing the sponge effect of UCA1 for miR-122-5p. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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