Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | breast cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | We found that treatment with macrophage CM induced the expression of numerous lncRNAs, including urothelial cancer associated 1 (UCA1). Knockdown of UCA1 using shRNA inhibited AKT phosphorylation and abolished invasiveness of tumor cells induced by macrophage CM. Consistent with these results; we further showed that UCA1 level was significantly enhanced in human primary breast tumors and correlated with advanced clinical stage, supporting its role in promoting carcinogenesis and progression of breast cancer |
| Pubmed ID | 26464647 |
| Year | 2015 |
| Title | Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1 |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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