Detail
| LncRNA Name | AC023115.3 |
| Synonyms | NA |
| Region | GRCh38_2:67324627-67325304 Sequence |
| Ensembl | ENSG00000236605 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | qPCR, westen blot, microarray etc. |
| Sample | cell lines (U87MG and U251MG) |
| Expression Pattern | down-regulated |
| Function Description | AC023115.3 was preferentially enriched in the Ago2-containing microRNA ribonucleoprotein complexes (miRNPs) compared with the immunoprecipitates with control IgG,indicating that AC023115.3 is present in the Ago2-containing miRNPs likely through an association with microRNAs. AC023115.3 was induced by cisplatin and suppressed glioma chemoresistance.AC023115.3 inhibited cisplatin-induced autophagy. AC023115.3 promoted cisplatin-induced apoptosis via decreasing autophagy. AC023115.3 acted as a miR-26a sponge and inhibited its activity. AC023115.3 sensitized glioma cell to cisplatin-induced apoptosis through regulation of the miR-26a-GSK3B-Mcl1 signalling. |
| Pubmed ID | 28499919 |
| Year | 2017 |
| Title | Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy |
| External Links |
| Links for AC023115.3 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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