UCA1 was upregulated in HRGC cells, which promoted their migration.miR-7-5p could bind to specific sites of UCA1 to regulate the target EGFR through competitive endogenous RNA function.UCA1 directly interacted with miR-7-5p and decreased the binding of miR-7-5p to the EGFR 3'-untranslated region,which suppressed the degradation of EGFR mRNA by miR-7-5p.Therefore,long-term hypoxia induced UCA1 to promote cell migration by enhancing the expression of EGFR.This study thus reveals a new mechanism by which a hypoxic microenvironment promotes tumor metastasis, and highlights UCA1 as a potential biomarker for predicting the metastasis of gastric cancer to guide clinical treatment.