Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name UCA1
   Synonyms UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36
   Region GRCh38_19:15828206-15836326    Sequence
   Ensembl ENSG00000214049
   RefSeq NR_015379
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name gastric cancer
   ICD-0-3 C16  
   Methods qPCR etc.
   Sample cell lines (HEK-293, HUVECs, SKBR3, A542, MCF7, NT2)
   Expression Pattern up-regulated
   Function Description

Our results showed ecCEBPA and UCA1 over-expression in GC tissues. Furthermore, lncRNAs associations with clinicopathological features were demonstrated both in the current and TCGA cohort. Kaplan-Meier analysis indicated that patients with higher UCA1 expression had a worse overall survival in the case of pancreatic and lung adenocarcinomas but not other solid cancer types including GC. These data demonstrate UCA1 and ecCEBPA involvement in GC and suggest that these lncRNAs might be useful as diagnostic/ prognostic biomarkers in cancer.

   Pubmed ID 29147491
   Year 2017
   Title Augmented expression levels of lncRNAs ecCEBPA and UCA1 in gastric cancer tissues and their clinical significance
   External Links
   Links for  UCA1 GenBank       HGNC       lncrnadb       Noncode
   Links for  gastric cancer Omim       Cosmic

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