Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (5637, T24) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA-UCA1 was upregulated by hypoxia in bladder cancer cells. Under hypoxic conditions, lncRNA-UCA1 upregulation increased cell proliferation, migration, and invasion and inhibited apoptosis. The underlying mechanism of hypoxia-upregulated lncRNA-UCA1 expression was that HIF-1a specifically bound to HREs in the lncRNA-UCA1 promoter. Furthermore, HIF-1a knockdown or inhibition could prevent lncRNA-UCA1 upregulation under hypoxia. |
| Pubmed ID | 24737584 |
| Year | 2014 |
| Title | Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1a-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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