Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, ChIP, Luciferase reporter assay etc. |
| Sample | cell lines (BLZ-211 and BLS-211) |
| Expression Pattern | differential expression |
| Function Description | To verify if Ets-2 induced UCA1 gene expression was involved in apoptosis we studied another bladder TCC cell line, called BLS-211. BLS-211 is lack of endogenous UCA1 expression and is derived from the same patient as BLZ-211 cell line. Interestingly, after knocking down the Ets-2 gene, we didnā??t observed subsequent apoptosis in BLS-211 cells. Additionally, we counted the apoptotic cells using flow cytometry in both cell lines separately. Consistent with the fluorescence microscope results, the flow cytometry results revealed a significant increase of cell pro-apoptosis (upper right quadrant) after Ets-2 knockdown in BLZ-211 cells while no increase of pro-apoptosis was observed after Ets-2 knockdown in BLS-211 cells. These results suggested that UCA1 may be involved in the cell apoptosis induced by the suppression of the Ets-2. |
| Pubmed ID | 24069250 |
| Year | 2013 |
| Title | Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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