UCA1 is significantly higher in GC tissues and cells compared with adjacent normal tissues and a gastric epithelium cell line,respectively. Higher UCA1 expression was associated with lymph node metastasis,TNM stage,and poor overall survival (OS) in GC patients.In vitro functional studies confirmed that UCA1 promotes cell proliferation,colony formation ability,and cell invasion in GC cells. We demonstrated that knockdown of UCA1 inhibits tumor growth in vivo. The double luciferase reporter,RNA-binding protein immunoprecipitation assay, and RNA pull down assay demonstrated that miR-590-3p serves as a target for UCA1. Moreover,we demonstrated that CREB1 is a downstream target of miR-590-3p and UCA1 activates CREB1 expression by sponging to miR-590-3p.