Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RIP, Luciferase reporter assay etc. |
| Sample | breast cancer tissue, cell line MDA-MB-231-luc-D3H2LN |
| Expression Pattern | up-regulated |
| Function Description | We observed that TGF-B induced genome-wide changes in lncRNA levels in breast cancer cells, among which AC026904.1 and UCA1 were highly expressed in metastatic breast cancer and closely associated with poor prognosis. UCA1 exerts a competitive endogenous RNA (ceRNA) activity in the cytoplasm. |
| Pubmed ID | 29774079 |
| Year | 2018 |
| Title | Long non-coding RNAs AC026904.1 and UCA1: a â??one-two punchâ?? for TGF-B-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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