Detail
| LncRNA Name | UCA1 |
| Synonyms | UCA1, CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36 |
| Region | GRCh38_19:15828206-15836326 Sequence |
| Ensembl | ENSG00000214049 |
| RefSeq | NR_015379 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RNAI, etc. |
| Sample | cell lines (SW480, NF) |
| Expression Pattern | up-regulated |
| Function Description | Our results revealed that CAFs could induce upregulation of UCA1, leading to upregulation of mTOR. Up-regulation of UCA1/mTOR axis suppressed p27 and miR-143 while the expression of Cyclin-D1 and KRAS were significantly increased compared with control. Results verified that CAFs induce the EMTTFs and consequently E-cadherin was remarkably down-regulated |
| Pubmed ID | 29948578 |
| Year | 2018 |
| Title | Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1. |
| External Links |
| Links for UCA1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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