Detail
| LncRNA Name | VIM-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:17214239-17229985 Sequence |
| Ensembl | ENSG00000229124 |
| RefSeq | NR_108061 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (SW1116, SW480, HT29, SW48), colorectal cancer tissue |
| Expression Pattern | up-regulated |
| Function Description | VIM-AS1 transcript was significantly upregulated in high-grade, lymph node metastasis and vascular invasion tumors.The downregulation of VIM-AS1 could inhibit tumor cell proliferation by inducing apoptosis, cellular senescence and arresting the cell cycle.VIM-AS1 might play a crucial role in cell migration as well as the epithelial to mesenchymal transition (EMT) of CRC cells. VIM-AS1 promotes tumor growth and metastasis by inducing EMT in CRC cells and could be considered as a novel tumor marker with probable value in diagnosis and CRC treatment. |
| Pubmed ID | 29656793 |
| Year | 2018 |
| Title | Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT. |
| External Links |
| Links for VIM-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.