Detail
| LncRNA Name | WT1-AS |
| Synonyms | WT1-AS, WIT-1, WIT1, WT1-AS1, WT1AS |
| Region | GRCh38_11:32435518-32458769 Sequence |
| Ensembl | ENSG00000183242 |
| RefSeq | NR_023920 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | HCC tissues |
| Expression Pattern | down-regulated |
| Function Description | WT1-AS expression correlated negatively with WT1 expression in HCC tumor tissue. Kaplan-Meier curve analysis revealed that WT1-AS expression is a reliable indicator of HCC prognosis. The downregulation of WT1 expression by WT1-AS promoted cell apoptosis by suppressing the JAK/STAT3 signaling pathway. Bioinformatics analysis showed that WT1-AS downregulates WT1 by binding to the TATA region of the WT1 promotor. WT1-AS was also able to reverse WT1-mediated resistance to Dox based chemotherapy in HCC cells |
| Pubmed ID | 26462627 |
| Year | 2015 |
| Title | WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1 |
| External Links |
| Links for WT1-AS | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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