Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | leukemia |
| ICD-0-3 | M9800/3 |
| Methods | qPCR, ISH etc. |
| Sample | blood, bone marrow |
| Expression Pattern | down-regulated |
| Function Description | We have localised the breakpoints on two acquired isodicentric X chromosomes associated with leukaemia to a 450 kilobase region of DNA within Xq13, which result in deletion of the XIST gene. We have demonstrated that these chromosomes remain inactive and that there is no evidence of XIST expression from the remaining intact X chromosomes. The data suggest that XIST is not required for the maintenance of X-inactivation on these somatically rearranged X chromosomes. |
| Pubmed ID | 7981672 |
| Year | 1994 |
| Title | Absence of the XIST gene from late-replicating isodicentric X chromosomes in leukaemia. |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for leukemia | Omim Cosmic |
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