Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | microarray, qPCR etc. |
| Sample | ovarian cancer tissues, cell lines (ALST, CAOV3, OVCA3 etc.) |
| Expression Pattern | down-regulated |
| Function Description | The clinical relevance of this observation is demonstrated by the strong association between XIST RNA levels and disease-free periods of ovarian cancer patients in a group of 21 ovarian cancer cases with Taxol in the therapeutic regiments. Cytogenetic studies on ovarian cancer cell lines indicated that loss of inactive X chromosome is one mechanism for the loss of XIST transcripts in the cell lines. Our data suggest that XIST expression may be a potential marker for chemotherapeutic responses in ovarian cancer. |
| Pubmed ID | 12492109 |
| Year | 2002 |
| Title | Relationship of XIST expression and responses of ovarian cancer to chemotherapy. |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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