Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blotting, Luciferase reporter assay etc. |
| Sample | cell lines (MG63, U2OS, Saos2, HOS, SOSP-9697, SV40) |
| Expression Pattern | down-regulated |
| Function Description | XIST regulated PDCD4 expression by competitively binding to miR-21-5p. XIST inhibited cell proliferation and cell mobility by competitively binding to miR-21-5p and upregulating PDCD4 in OS. Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR-21-5p to maintain the expression of PDCD4, which contributes to the progression of OS. Our fndings suggest that the newly identifed XIST/miR-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS. |
| Pubmed ID | 29048648 |
| Year | 2017 |
| Title | Long non-coding RNA XIST regulates PDCD4 expression by interacting with miR-21-5p and inhibits osteosarcoma cell growth and metastasis |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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