X inactive-specific transcript gene amplification has also been detected in microsatellite-unstable sporadic human CRC tissue when compared to matched normal colorectal epithelium. aCGH revealed distinct DNA copy number changes between sporadic CIN- and MIN-associated colorectal carcinomas. A differential role of these candidate oncogenes and tumor suppressor genes in tumor development and progression of sporadic CIN and MIN CRC is likely and may also be involved in the response or resistance to therapeutic interventions, such as shown for microsatellite instability and 5-FU.