Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | hepatocellular carcinoma tumor tissues, cell lines (MHCC97L, MHCC97H, HepG2, SMMC7221, Huh7, Bel-7402) |
| Expression Pattern | down-regulated |
| Function Description | XIST was significantly upregulated in HCC tissues and associated with tumor size and vascular invasion.Gain- and loss-of-function of XIST further presented that XIST promoted the progression of HCC cells, including proliferation, migration,and invasion. Moreover, silencing of XIST could inhibit tumor growth in vivo. XIST could target miR-194-5p and thus decrease miR-194-5p expression.Besides that,restoring XIST could reverse the inhibitory effect of miR-194-5p on the proliferation and invasion of HCC cells. We further elucidated such rescue role might through derepressing MAPK1 expression,the target of miR-194-5p.We pinpointed that LncRNA XIST can act as a ceRNA for MAPK1 mRNA through miR-194-5p. These results deepen our understanding of the role of XIST in HCC. |
| Pubmed ID | 29227532 |
| Year | 2018 |
| Title | LncRNA XIST functions as a molecular sponge of miR-194-5p to regulate MAPK1 expression in hepatocellular carcinoma cell. |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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