Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR |
| Sample | osteosarcoma tissues, cell lines (HOS, SAOS-2,SOSP-9607, MG63, and U2-OS and hFOB 1.19) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that XIST was significantly up-regulated in osteosarcoma tissues and cell lines, and high XIST expression was significantly associated with advanced tumor size (p=0.009), advanced clinical stage (p=0.001) and present distant metastasis (p=0.009). Kaplan-Meier analysis showed that increased XIST expression was associated with poor overall survival of patients. |
| Pubmed ID | 28682435 |
| Year | 2017 |
| Title | High expression of long non-coding RNA XIST in osteosarcoma is associated with cell proliferation and poor prognosis |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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