Detail
| LncRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 Sequence |
| Ensembl | ENSG00000229807 |
| RefSeq | NR_001564 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, western blot, Luciferase reporter assays etc. |
| Sample | non small cell lung cancer tissues, cell lines (A549, H358, H460, H1299, and PC9) |
| Expression Pattern | up-regulated |
| Function Description | We confirmed that XIST is aberrantly upregulated in NSCLC tissues and cell lines. XIST depletion inhibited cell proliferation and TGF-b1-induced EMT in A549 and H1299 cells.We identified a branch of the XIST/miR-137/Notch-1 pathway that regulates proliferation and TGF-b1-induced EMT in NSCLC, which could be involved in NSCLC progression. |
| Pubmed ID | 29812958 |
| Year | 2018 |
| Title | Knockdown of LncRNA-XIST Suppresses Proliferation and TGF-β1-Induced EMT in NSCLC Through the Notch-1 Pathway by Regulation of miR-137 |
| External Links |
| Links for XIST | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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