Detail
| LncRNA Name | CADM1-AS1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 M8005/0 |
| Methods | qPCR, RNAi etc. |
| Sample | renal cancer tissues, cell lines (786-O, ACHN etc.) |
| Expression Pattern | down-regulated |
| Function Description | The results showed that CADM1-AS1 expression was down-regulated in tumor tissues in 64 patients with ccRCC compared with adjacent non-tumor tissues. Furthermore, the expression of CADM1-AS1 was positively correlated with the expression of mRNA CADM1 in ccRCC specimens. Decreased CADM1-AS1 expression was correlated with the progression of AJCC stage and worse survival of ccRCC patients. Also, multivariate analysis identified low CADM1-AS1 expression as an independent prognostic factor for ccRCC.CADM1-AS1 is a new tumor suppressor in ccRCC which regulates cell proliferation, apoptosis and migration via the expression pattern of CADM1-AS1/CADM1 mRNA gene pairs. |
| Pubmed ID | 25031695 |
| Year | 2014 |
| Title | Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas. |
| External Links |
| Links for CADM1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for clear cell renal cell carcinoma | Omim Cosmic |
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