Detail
| LncRNA Name | Z38 |
| Synonyms | CLDND1, Z38, C3orf4, GENX-3745 |
| Region | GRCh38_3:98497912-98523066 Sequence |
| Ensembl | ENSG00000080822 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (MDA-MB-231, MCF-7, Hela, PL45, SW480, U251, A549, Hep G2 etc.) |
| Expression Pattern | up-regulated |
| Function Description | In the current study, a newly found lncRNA Z38, which was identified through combining experiments of suppression subtractive hybridization (SSH) and reverse dot-blotting, was found to have high expression in breast cancer. More importantly, inhibiting Z38 expression by gene silencing greatly suppressed breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induced cell apoptosis and inhibited tumor growth. |
| Pubmed ID | 27053956 |
| Year | 2016 |
| Title | High Expression of the Newly Found Long Noncoding RNA Z38 Promotes Cell Proliferation and Oncogenic Activity in Breast Cancer |
| External Links |
| Links for Z38 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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