Detail
| LncRNA Name | ZEB1-AS1 |
| Synonyms | NR_024284 |
| Region | GRCh38_10:31206278-31320447 Sequence |
| Ensembl | ENSG00000237036 |
| RefSeq | NR_024284 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | B cell acute lymphoblastic leukemia |
| ICD-0-3 | M9826/3 |
| Methods | qPCR, Western blot, RIP |
| Sample | B-lineage acute lymphoblastic leukemia blood, cells (BMSC, HS-5, BALL-1) |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 levels were aberrantly up-regulated in B-ALL. All correlated with STAT3 activation and IL-11 production.a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. Mechanistically, ZEB1-AS1 could bind to IL-11 and promote IL-11 stability. Down-regulation of ZEB1-AS1 decreased IL-11 production of human bone marrow stromal cells (BMSCs), which led to suppressed proliferation and inhibited IL-11/STAT3 pathway in BALL-1 cells. ZEB1-AS1 promotes the activation of IL-11/STAT3 signaling pathway by associating with IL-11 in B-ALL. |
| Pubmed ID | 28861713 |
| Year | 2017 |
| Title | LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia. |
| External Links |
| Links for ZEB1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for B cell acute lymphoblastic leukemia | Omim Cosmic |
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