Detail
| LncRNA Name | ZEB1-AS1 |
| Synonyms | NR_024284 |
| Region | GRCh38_10:31206278-31320447 Sequence |
| Ensembl | ENSG00000237036 |
| RefSeq | NR_024284 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | CRC tissues, CRC cell lines (SW480, DLD-1, HCT116, SW620, and HT29) |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 was upregulated in CRC tissues and cells.MiR-101 was downregulated in CRC tissues and negatively correlated with ZEB1-AS1 and ZEB1 expression levels in CRC. Functional experiments showed that, consistent with ZEB1-AS1 depletion,miR-101 overexpression and ZEB1 depletion inhibited the proliferation and migration of CRC cells. Overexpression of miR-101 partially abolished the effects of ZEB1-AS1 on the proliferation and migration of these cells. Moreover, combined ZEB1-AS1 depletion and miR-101 overexpression significantly inhibited cell proliferation and migration of the CRC cells. Hence, ZEB1-AS1 functioned as a molecular sponge for miR-101 and relieved the inhibition of ZEB1 caused by miR-101. |
| Pubmed ID | 29511455 |
| Year | 2018 |
| Title | Interplay between long noncoding RNA ZEB1-AS1 and miR-101/ZEB1 axis regulates proliferation and migration of colorectal cancer cells. |
| External Links |
| Links for ZEB1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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